Anti-ADAMTS-12 antibody produced in chicken

半岛bd体育手机客户端 说明

一般描述

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme encoded by the ADAMTS12 gene in humans. It belongs to the family of metalloproteinases that helps in mediating a communication between specific cell types and plays a key role in the regulation of normal tissue development, remodeling and degradation.

免疫原

Immunogen Sequence: GI # 13569928, sequence 297-446
Recombinant A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 12

应用

Anti-ADAMTS-12 antibody produced in chicken is suitbale for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

ADAMTS12 is a degradative enzyme that interacts with the degradable fragments of cartilage oligomeric matrix protein, which is a prominent non-collagenous matrix component in articular cartilage. The protein exhibits a propeptide and metalloproteinase-like, disintegrin-like cysteine-rich domains. It may play a crutial role in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. ADAMTS12 is found in cartilage, synovial fluid and serum of arthritic patients and may play an important role in the pathogenesis of arthritis. It may be a susceptibile gene for rheumatoid arthritis development. The genetic variations in ADAMTS12 is found to influence the risk of schizophrenia.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	chicken
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	mouse, human, rat
manufacturer/tradename	Genway 15-288-22831
technique(s)	western blot: suitable
NCBI登记号	NP_112217.1
UniProt登记号	P58397
运输	wet ice
储存温度	?20℃
Gene Information	human ... ADAMTS12(81792)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)