Angiogenesis Inhibitor-CAS 186611-44-9-Calbiochem

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一般描述

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 ?M in anin vitrorat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 ?M). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 ?M).
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 ?M in anin vitrorat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 ?M). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 ?M).

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 54% inhibition at 10 ?M against hEGF-R tyrosine kinase activity
Reversible: no
Product competes with ATP.
Primary Target
hEGF-R tyrosine kinase activity

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Braud, E., et al. 2003.J. Enzyme Inhib. Med. Chem.18,243.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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