半岛bd体育手机客户端 说明
一般描述
An irreversible blocker of NF-κB and AP-1 (IC50≤ 15 ?M) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50≤ 15 ?M) activation, and preventsin vitroandin vivoT cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
包装
50 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
NF-κB and AP-1 activation
Product does not compete with ATP.
Reversible: no
Target IC50: ≤ 15 ?M against NF-κB and AP-1 activation
Cell permeable: no
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Xia, Y.F., et al. 2004.J. Immunol.173,4207.
Chen, J.H., et al. 2004.Biochem. Pharmacol.67,1337.
Yu, B.C., et al. 2003.Planta Med.69,1075.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H30O5 |
| 分子量 | 350.45 |
| MDL编号 | MFCD07778082 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | chloroform: methanol (1:1): 10 mg/mL DMSO: 15 mg/mL (Use only fresh DMSO.) |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16?,17?,19+,20?/m1/s1 |
| InChI key | BOJKULTULYSRAS-ZJFCSBQFSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
