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位置: 首页> 品牌> Sigma-Aldrich> Anaphase-Promoting Complex Inhibitor, TAME-CAS 1784-03-8-Calbiochem

Anaphase-Promoting Complex Inhibitor, TAME-CAS 1784-03-8-Calbiochem

品牌
Sigma-Aldrich
CAS
1784-03-8
货号
172104
规格纯度
The Anaphase-Promoting Complex Inhibitor, TAME, also referenced under CAS 1784-03-8, controls the biological activity of Anaphase-Promoting Complex. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
价格
1164.01 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
1784-03-8
Anaphase-Promoting Complex Inhibitor, TAME-CAS 1784-03-8-Calbiochem
TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50= 12 ?M.

包装

50 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Sackton, K.L., et al. 2014.Nature.In press.
Zeng, X., et al. 2010.Cancer Cell18,382.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H22N4O4S · xHCl
分子量 342.41 (free base basis)
MDL编号 MFCD00012578

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
InChI key JIQFFACVQXXHMY-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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