半岛bd体育手机客户端 说明
一般描述
A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd~18 ?M) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd~18 ?M) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
包装
2 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Primary Target
Akt
Reversible: yes
Kd ~18 ?M in binding to Akt-PH domain
Cell permeable: no
警告
Toxicity: Carcinogenic / Teratogenic (D)
序列
H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
外形
Supplied as an acetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Hiromura, M., et al. 2004.J. Biol. Chem.279,53407.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C88H123N23O23 |
| 分子量 | 1871.06 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | lyophilized solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: 1 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
