Adenylyl Cyclase Type V Inhibitor, NKY80-CAS 299442-43-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀= 8.3 ?M, 132 ?M and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
A cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC₅₀= 8.3 ?M, 132 ?M and 1.7 mM for type V, III and II, respectively) in the presence of G₅α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.

包装

5, 25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Adenylate cyclase (AC) type V isoform
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 8.3 ?M, 132 ?M and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Onda, T., et al. 2001.J. Biol. Chem.276,47785.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C12H11N3O2
分子量	229.23
MDL编号	MFCD02026323

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	pale orange
溶解性	DMSO: 200 mg/mL methanol: 5 mg/mL
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable