A1V2PF2-NHEt-C<sub>10</sub>-NH<sub>2</sub>

A1V2PF2-NHEt-C₁₀-NH₂

品牌

Sigma-Aldrich

货号

916684

包装型号

50 MG, ≥95%

规格纯度

≥95%

价格

1857.67 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

A1V2PF2-NHEt-C ₁₀-NH ₂
AVP conjugate for IAP-mediated degrader development" to "AVP conjugate for IAP-mediated protein degrader development
SNIPER building block
( S)-1-(( S)-2-(( S)-2-((10-Aminodecyl)amino)propanamido)-2-cyclohexylacetyl)- N-(( S)-1-(ethylamino)-3-(4-fluorophenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Protein degrader building block A1V2PF2-NHEt-C₁₀-NH₂enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^?degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
916714 A1V2PF2-NHEt
917931 A1V2PF2-NHEt-C₆-NH₂
916684 A1V2PF2-NHEt-C₁₀-NH₂
916935 A1V2PF2-NHEt-PEG₁-NH₂
917192 A1V2PF2-NHEt-PEG₃-NH₂

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

其他说明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs?Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₇H₆₁FN₆O₄
分子量	672.92

半岛bd体育手机客户端性质

质量水平	100
测定	≥95%
形式	powder
储存温度	2-8℃
SMILES string	C[C@H](NCCCCCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O C[C@H](NCCCCCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

A1V2PF2-NHEt-C10-NH2

A1V2PF2-NHEt-C₁₀-NH₂