A1V1PF2-OEt-PEG<sub>1</sub>-NH<sub>2</sub> hydrochloride

A1V1PF2-OEt-PEG₁-NH₂hydrochloride

品牌

Sigma-Aldrich

货号

917923

包装型号

50 MG

规格纯度

价格

3513.6 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

A1V1PF2-OEt-PEG ₁-NH ₂hydrochloride
AVP conjugate for IAP-mediated protein degrader development
Ethyl ( S)-2-(( S)-1-(( S)-2-(( S)-2-((2-(2-aminoethoxy)ethyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate hydrochloride
SNIPER building block

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Protein degrader building block A1V1PF2-OEt-PEG₁-NH₂hydrochloride enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^?degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
917710 A1V1PF2-OEt
917427 A1V1PF2-OEt-C₆-NH₂hydrochloride
917672 A1V1PF2-OEt-C10-NH₂hydrochloride
917923 A1V1PF2-OEt-PEG₁-NH₂hydrochloride
916676 A1V1PF2-OEt-PEG₃-NH₂hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

其他说明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs?Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₂₉H₄₆FN₅O₆· xHCl
分子量	579.70 (free base basis)

半岛bd体育手机客户端性质

形式	powder
质量水平	100
储存温度	2-8℃
SMILES string	C[C@H](NCCOCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl C[C@H](NCCOCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

A1V1PF2-OEt-PEG1-NH2hydrochloride

A1V1PF2-OEt-PEG₁-NH₂hydrochloride