半岛bd体育手机客户端 说明
一般描述
A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
包装
50 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
protein carboxymethyltranferase
Secondary Target
FGF-2receptor tyrosine kinase activity
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
其他说明
Lee, S.H., and Cho, Y.D. 1998.Exp. Cell Res.240,282.
Smalheiser, N.R. 1998.Brain Res. Dev. Brain Res.51,53.
Joy, A., et al. 1997.Oncogene14,171.
Riscoe, M.K., et al. 1984.Biochem. Pharmacol.33,3639.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C11H15N5O3S |
| 分子量 | 297.33 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMF: 25 mg/mL DMSO: soluble |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| InChI | 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14) |
| InChI key | WUUGFSXJNOTRMR-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
