半岛bd体育手机客户端 说明
应用
4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride is an alkyne-functionalized sulfonyl fluoride activity-based probe (SFABP). Sulfonyl fluorides covalently modify reactive serines in addition to threonine, lysine, tyrosine, cysteine, and histidine residues in a context-specific manner. Activity-based probes are useful for the targeting, isolation, and identification of proteins. Furtermore, the alkyne handle on SFABP enables click chemistry-based incorpoation of azide tags, such as fluorophores or biotins, for visualization or enrichment and detection, respectively.
其他说明
Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides
Sulfonyl fluorides as privileged warheads in chemical biology
Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferase
Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases
Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS
基本信息
经验(实验)分子式 | C14H16FNO3S |
分子量 | 297.35 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥95% |
形式 | powder |
储存温度 | ?20℃ |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H315 - H319 |
预防措施声明 | P302 + P352 - P305 + P351 + P338 |
危险分类 | Eye Irrit. 2 - Skin Irrit. 2 |
储存分类代码 | 11 - Combustible Solids |
Sigma-Aldrich