3-Nitropropionic acid-CAS 504-88-1-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.

包装

50 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Beal, M., et al. 1993,J. Neurosci.13,4181.
Pang, Z., et al. 1997,J. Neuroscience17,3064.
Huang, L., et al. 2006,J. Bio. Chem.281,5965.
Garcia, M., et al. 2002,J. Neurosci.22,2174.
Kim, G. W., et al. 2003,J. Neurosci.23,8733.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C3H5NO4
分子量	119.08
MDL编号	MFCD00007406

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (NMR)
形式	powder
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	light yellow
溶解性	ethanol: 100 mg/mL DMSO: soluble
运输	ambient
储存温度	2-8℃
InChI	1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key	WBLZUCOIBUDNBV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable