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位置: 首页> 品牌> Sigma-Aldrich> 2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid

2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid

品牌
Sigma-Aldrich
货号
920592
包装型号
规格纯度
价格
6135.79 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
2-(2-( tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid
Rigid linker for PROTAC development
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

2-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920711
920614
920622
920630

其他说明

Portal: Building PROTAC?Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C20H26N2O5
分子量 374.43

半岛bd体育手机客户端 性质

形式 powder
质量水平 100
储存温度 2-8℃
SMILES string CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=CC=C3C(O)=O)C1)=O)C
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=CC=C3C(O)=O)C1)=O)C

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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