(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2 hydrochloride

(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH₂hydrochloride

品牌

Sigma-Aldrich

货号

920606

包装型号

50 MG

规格纯度

价格

6641.72 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

( S, R, S)-AHPC-piperazine-pyridine-alkyne-NH ₂hydrochloride
Protein degrader building block for PROTAC research
(2 S,4 R)-1-(( S)-2-(4-(4-(5-(3-Aminoprop-1-yn-1-yl)pyridin-2-yl)piperazin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy- N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Crosslinker-E3 Ligase ligand conjugate
VH032 conjugate
Template for synthesis of targeted protein degrader

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Protein degrader building block (S,R,S)-AHPC-piperazine-pyridine-alkyne-NH₂hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^?Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₈H₅₀N₈O₄S · xHCl
分子量	714.92 (free base basis)

半岛bd体育手机客户端性质

质量水平	100
形式	powder or crystals
储存温度	2-8℃
SMILES string	CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl

(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2hydrochloride

(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH₂hydrochloride