(S,R,S)-AHPC-PEG2-butyl CO2H

(S,R,S)-AHPC-PEG₂-butyl CO₂H

品牌

Sigma-Aldrich

货号

910600

包装型号

50 MG, ≥95%

规格纯度

≥95%

价格

5062.04 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

( S, R, S)-AHPC-PEG ₂-butyl CO ₂H
Protein degrader building block for PROTAC research
VH032 conjugate
7-(2-(2-((( S)-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethoxy)heptanoic acid
Template for synthesis of targeted protein degrader
( S, R, S)-AHPC-2-2-6-acid
Crosslinker-E3 Ligase ligand conjugate

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Protein degrader builiding block (S,R,S)-AHPC-PEG₂-butyl CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Building PROTAC^?Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₃H₄₈N₄O₈S
分子量	660.82

半岛bd体育手机客户端性质

测定	≥95%
形式	crystals
储存温度	2-8℃
SMILES string	O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC(O)=O.Cl O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC(O)=O.Cl

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable