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TCPOBOP-CAS 76150-91-9-Calbiochem

品牌
Sigma-Aldrich
CAS
76150-91-9
货号
580563
规格纯度
The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
价格
2538.8 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
76150-91-9
TCPOBOP-CAS 76150-91-9-Calbiochem
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genesmdr2andmdr3in mouse liver.
The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Cytochrome P450 (CYP)-inducing agents
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Ledda-Columbano, G.M., et al. 2000.Am. J. Pathol.156,91.
Moore, L.B., et al. 2000.J. Biol. Chem.275,15122.
Tzameli, I., et al. 2000.Mol. Cell. Biol.20,2951.
Forman, B.M., et al. 1998.Nature395,612.
Honkakoski, P., et al. 1998.Mol. Pharmacol.53,597.
Russell, A.L., et al. 1994.Int. J. Cancer58,550.
Smith, G., et al. 1993.Biochem. J.289,807.
Dargani, T.A., et al. 1990.Carcinogenesis11,1153.
Poland, A., et al. 1980.Mol. Pharmacol.18,571.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C16H8Cl4N2O2
分子量 402.06
MDL编号 MFCD00057368

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 5 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChI key BAFKRPOFIYPKBQ-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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