半岛bd体育手机客户端 说明
一般描述
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss 3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
包装
10 mg in Plastic ampoule
生化/生理作用
Primary Target
A potent mitogen
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
其他说明
Berger, A., et al. 1995.Proc. Natl. Acad. Sci. USA92,5885.
Dettbarn, C., et al. 1995.Brain Res.669,79.
Seufferlein, T. and Rozengurt, E. 1995.J. Biol. Chem.270,24343.
Seufferlein, T. and Rozengurt, E. 1995.J. Biol. Chem.270,24334.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H49N2O5P |
| 分子量 | 464.62 |
| MDL编号 | MFCD02259287 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated |
| 颜色 | white |
| 溶解性 | chloroform/methanol (2:1): 1 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
