半岛bd体育手机客户端 说明
一般描述
A cell-permeable inhibitor of calpain I (Ki= 120 nM), calpain II (Ki= 230 nM), cathepsin B (Ki= 100 nM), and cathepsin L (Ki= 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Cell permeable inhibitor of calpain I (Ki= 120 nM), calpain II (Ki= 230 nM), cathepsin B (Ki= 100 nM), and cathepsin L (Ki= 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
包装
25 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target Ki: 120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Product does not compete with ATP.
Reversible: no
Primary Target
calpain-1
警告
Toxicity: Standard Handling (A)
序列
N-Acetyl-Leu-Leu-Met
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Ravid, T., et al. 2000.J. Biol. Chem.275,35840.
Griscavage, J.M., et al. 1995.Biochem. Biophys. Res. Commun.215,721.
Sarin, A., et al. 1994.J. Immunol.153,862.
Sarin, A., et al. 1993.J. Exp. Med.178,1693.
Banik, N.L., et al. 1992.Neurochem. Res.17,797.
Koohmaraie, M. 1992.Biochemie74,239.
Pinter, M., et al. 1992.Biochemistry31,8201.
Shenoy, A.M., and Brahmi, Z. 1991.Cell. Immunol.138,24.
Sasaki, T., et al. 1990.J. Enzyme Inhib.3,195.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H35N3O4S |
| 分子量 | 401.56 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | >95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | off-white |
| 溶解性 | DMSO: 5 mg/mL ethanol: 5 mg/mL methanol: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1 |
| InChI key | RJWLAIMXRBDUMH-ULQDDVLXSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
