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TNP-470-CAS 129298-91-5-Calbiochem

品牌
Sigma-Aldrich
CAS
129298-91-5
货号
654270
规格纯度
A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity of MetAP2 against HRI- catalyzed eIF-2α phosphorylation.
价格
2313.1 *本价格含增值税费
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半岛bd体育手机客户端 名称:
129298-91-5
TNP-470-CAS 129298-91-5-Calbiochem
AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50= 1 nM against human MetAP2) by covalently modifying MetAP2 active site histidine (aa 231 in human/mouse/rat; aa 174 in yeast) via its epoxide group, without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. Cellular MetAP2 inhibition is particularly effective in inducing endothelial cytostasis (IC50= 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC proliferation by TNP-470), making TNP-470 a potent anti-angiogenesis agentin vivo(2 to 100 mg/kg in mice and rats; s.c.). Reported to be more potent and less toxic than Fumagillin.
A cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50= 1 nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50= 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC)in vitroand an effective anti-angiogenesis agentin vivo(2 to 100 mg/kg in mice and rats; s.c.).

包装

10 mg in Glass bottle

警告

Toxicity: Irritant (B)

其他说明

Zhang, Y., et al. 2000.Proc. Natl. Acad. Sci. USA97,6427.
Sin, N., et al.Proc. Natl. Acad. Sci. USA94,6099.
Yamaoka, M., et al. 1993.Cancer Res.53,4262.
Kusaka, M., et al. 1991.Biochem. Biophys. Res. Commun.174,1070.
Ingber, D., et al. 1990.Nature348,555.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C19H28ClNO6
分子量 401.88

半岛bd体育手机客户端 性质

质量水平 200
测定 ≥97% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
颜色 white to light yellow
溶解性 DMSO: 100 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
InChI key MSHZHSPISPJWHW-PVDLLORBSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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