SU11652-CAS 326914-10-7-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC₅₀= 3 nM), VEGFR2 (IC₅₀= 27 nM), FGFR1 (IC₅₀= 170 nM), and Kit family members (IC₅₀= ~ 10-500 nM) over EGFR (IC₅₀>20 ?M). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.
A cell-permeable, potent, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of PDGFRβ (IC₅₀= 3 nM), VEGFR2 (IC₅₀= 27 nM), FGFR1 (IC₅₀= 170 nM), and Kit family members (IC₅₀~10-500 nM). Does not effect the activity of EGFR (IC₅₀>20 ?M). Reported to display anti-proliferative, antiangiogenic and pro-apoptotic properties in tumor cells.

包装

500 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively
Primary Target
PDGFRB
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Heryanto, B., et al. 2003.Reproduction125,334.
Sun, L., et al. 2003.J. Med. Chem.46,1116.
Liao, A.T., et al. 2002.Blood100,585.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息