SB 290157-CAS 1140525-25-2-Calbiochem

品牌

Sigma-Aldrich

CAS

1140525-25-2

货号

559410

包装型号

10 MG, A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC?? = 200 nM).

规格纯度

A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC₅₀= 200 nM).

价格

1988.74 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

1140525-25-2
SB 290157-CAS 1140525-25-2-Calbiochem
N ²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A non-peptide with anti-inflammatory properties that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (C3aR; IC₅₀= 200 nM). Does not antagonize C5aR or other chemotactic G-protein coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca²⁺mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC₅₀= 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from guinea pig platelets (IC₅₀= 30 nM).
A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC₅₀= 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca²⁺mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC₅₀= 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC₅₀= 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC₅₀: 200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
Primary Target
C3a receptor
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.

其他说明

Ames, R.S., et al. 2001.J. Immunol.166,6341.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₂₈N₄O₄· xC₂HF₃O₂
分子量	412.48 (free base basis)

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable