半岛bd体育手机客户端 说明
一般描述
LRP4 (low-density lipoprotein receptor-related protein 4a) is also called the multiple epidermal growth factor-like domains 7 (MEGF7). It is mapped to human chromosome 11p11.2. Low-density lipoprotein receptor-related protein 4a (LRP4) has epidermal growth factor repeat domain and four β-propeller domains.
应用
Suitable as a blocking agent using corresponding antibodies.
生化/生理作用
It modulates wnt signal transduction pathway. It is crucial for development of limbs and is essential for neuromuscular junction formation. Mutations in the LRP4 gene is associated with Cenani-Lenz syndrome (CLS), a disorder with abnormal distal limb development. Defective splicing of LRP4 leads to mulefoot disease. Mutations in the β-propeller domains of LRP4 is implicated in congenital myasthenic syndromes, a disorder of nerve impulse transmission.
联系
Corresponding Antibody HPA011934.
外形
Solution in 1 M urea-PBS, pH 7.4
制备说明
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
法律信息
Prestige Antigens is a trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 重组 | expressed inE. coli |
| 测定 | >80% (SDS-PAGE) |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 32 kDa |
| 纯化方式 | immobilized metal affinity chromatography (IMAC) |
| 浓度 | ≥0.5 mg/mL |
| 免疫原序列 | IQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSQPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAP |
| 基因组数据库 |人类登记号 | ENSG00000134569 |
| UniProt登记号 | O75096 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... LRP4(4038) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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