Polyester bis-MPA dendron

半岛bd体育手机客户端 说明

一般描述

• Polymer architecture: Dendron
• Generation: 3
• Core functional group: Boc-protected amine
• End Group Functionality: Alkyne
• No. Surface Groups: 8
• Calculated Mol. Wt.: 2283.21 g/mol
• Boc :tert-Butyloxycarbonyl
• bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.

应用

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

基本信息

经验(实验)分子式	C107H135NO53
分子量	2283.19
NACRES	NA.23

半岛bd体育手机客户端 性质

质量水平	100
形式	solid
分子量	generation 3
表面基团编号	8
颜色	white to off-white
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable