PD 158780-CAS 171179-06-9-Calbiochem

品牌

Sigma-Aldrich

CAS

171179-06-9

货号

513035

包装型号

500 μG, A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM).

规格纯度

A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC₅₀= 8 pM).

价格

2741.8 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

171179-06-9
PD 158780-CAS 171179-06-9-Calbiochem
4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC₅₀= 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC₅₀= 49 nM) and MDA-MB-453 (IC₅₀= 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase ? (MKK?) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC₅₀= 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC₅₀= 49 nM) and MDA-MB-453 (IC₅₀= 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH 3T3 cells. A 10 mM (500 ?g/151 ?l) solution of PD 158780 (Cat. No. 513036) in DMSO is also available.

包装

500 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 8 pM against EGFR tyrosine kinase activity; 49 nM, 52 nm, against heregulin-stimulated autophosphorylation in SK-BR-3 and MDA-MB-453 breast carcinomas, respectively
Primary Target
EGFR tyrosine kinase
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

其他说明

Cunnick, J.M., et al. 1998.J. Biol. Chem.273,14468.
Rewcastle, G.W., et al. 1998.J. Med. Chem.41,742.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₄H₁₂BrN₅
分子量	330.18
MDL编号	MFCD00942160

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3