NDGA-CAS 500-38-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, antioxidant and a selective lipoxygenase (LO) inhibitor (IC₅₀= 200 nM, 30 ?M, and 30 ?M for 5-LO, 12-LO, and 15-LO, respectively) over cyclooxygenase (IC₅₀= 100 ?M). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss 3T3 cells.
A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC₅₀= 200 nM, 30 ?M, and 30 ?M for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC₅₀= 100 ?M). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.

包装

250 mg in Glass bottle

生化/生理作用

Cell permeable: yes
Target IC₅₀: 200 nM, 30 ?M, and 30 ?M for 5-LOX, 12-LOX, and 15-LOX, respectively
Primary Target
LOX-5
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Domin, J., et al. 1994.J. Biol. Chem.269,8260.
Goodman, Y., et al. 1994.Brain Res.654,171.
Kozubik, A., et al. 1993.Exp. Hematol.21,138.
Salari, H., et al. 1984.Prostagland. Leuk. Med.13,53.
Hope, W.C., et al. 1983.Biochem. Pharmacol.32,367.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C18H22O4
分子量	302.36
MDL编号	MFCD00002206

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (HPLC)
形式	crystalline solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
溶解性	DMSO: 10 mg/mL ethanol: soluble
运输	ambient
储存温度	10-30℃
InChI	1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
InChI key	HCZKYJDFEPMADG-TXEJJXNPSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable