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Monoclonal Anti-IKBKE antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0009641M2
规格纯度
clone 2F1, purified immunoglobulin, buffered aqueous solution
价格
4888.5 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-IKBKE antibody produced in mouse
Anti-KIAA0151
Anti-MGC125294
Anti-IKKe
Anti-inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Anti-MGC125295
Anti-IKKi
Anti-MGC125297
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Inhibitor of κ light polypeptide gene enhancer in B-cells, kinase ε (IKKε ) is encoded by the gene mapped to human chromosome 1q32.1. IKKε is a serine/threonine protein kinase, which belongs to the non-canonical IκB kinase family. IKKε is an ~85kDa protein characterized with kinase domain close to N-terminal end, coiled-coil motif, and putative helix-loop-helix (HLH) motif close to C-terminal end.

免疫原

IKBKE (NP_054721, 541 a.a. ~ 640 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QQIQCYLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQE

生化/生理作用

Inhibitor of κ light polypeptide gene enhancer in B-cells, kinase ε (IKKε) mainly activates the canonical nuclear factor-κB (NF-κB) pathway induced by interferon, phorbol 12-myristate 13-acetate, or the T-cell receptor. Overexpression of IKKε is associated with the pathogenesis of a subset of breast tumors and ovarian cancer. IKBKE also acts as a potential therapeutic target for these malignancies. IKKε plays a vital role in regulation of immune response. IKKε is an essential constituent of a novel IκB kinase complex, which is mainly implicated in the degradation of IκBα in response to either phorbol esters (PMA) or to T cell receptor activation. IKKε activated by interferon-β (IFNβ), directly phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of interferon-stimulated gene factor 3 complex (ISGF3), and thus, plays a vital role in IFN-inducible antiviral transcriptional response.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 2F1, monoclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect ELISA: suitable
同位素/亚型 IgG1κ
GenBank?accession no. NM_014002
UniProt登记号 Q14164
运输 dry ice
储存温度 ?20℃
Gene Information human ... IKBKE(9641)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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