Lithium 2-(3-(4-(<i>tert</i>-butoxycarbonyl)-1,4-diazepan-1-yl)pyrazin-2-yl)acetate

Lithium 2-(3-(4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)pyrazin-2-yl)acetate

品牌

Sigma-Aldrich

货号

920681

包装型号

50 MG
100 MG

规格纯度

价格

2624.01 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Lithium 2-(3-(4-( tert-butoxycarbonyl)-1,4-diazepan-1-yl)pyrazin-2-yl)acetate
Rigid linker for PROTAC development
2-(3-(4-( tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazin-2-yl)acetate lithium salt

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Lithium 2-(3-(4-(tert-Butoxycarbonyl)-1; 4-diazepan-1-yl)pyrazin-2-yl)acetate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920517
920525

其他说明

Portal: Building PROTAC^?Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₁₆H₂₃LiN₄O₄
分子量	342.32

半岛bd体育手机客户端性质

形式	powder
质量水平	100
储存温度	2-8℃
SMILES string	CC(C)(OC(N1CCCN(C2=NC=CN=C2CC([O-])=O)CC1)=O)C.[Li+]

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Lithium 2-(3-(4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)pyrazin-2-yl)acetate