InSolution Staurosporine,Streptomycessp.

半岛bd体育手机客户端 说明

一般描述

A potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC₅₀= 20 nM), myosin light chain kinase (IC₅₀= 1.3 nM), protein kinase A (IC₅₀= 7 nM), protein kinase C (IC₅₀= 0.7 nM), and protein kinase G (IC₅₀= 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁checkpoint.

包装

100 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
Reversible: yes
Primary Target
PKA

警告

Toxicity: Irritant (B)

外形

A 1 mM (100 ?g/214 ?l) solution of Staurosporine (Cat. No. 569397) in DMSO.

重悬

Following initial thaw, aliquot, purge with inert gas, and freeze (-70°C).

其他说明

Couldwell, W.T., et al. 1994.FEBS Lett.345,43.
Nishimura, H. and Simpson, I.A. 1994.Biochem. J.302,271.
Bruno, S., et al. 1992.Cancer Res.52,470.
Kiss, Z. and Deli, E. 1992.Biochem. J.288,853.
Vitale, M.L., et al. 1992.Neuroscience51,463.
Hoffman, R. and Newland, E.S. 1991.Cancer Chemotherap. Pharmacol.28,102.
Oka, S., et al. 1986.Agric. Biol. Chem.50,2723.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C28H26N4O3
分子量	466.53
MDL编号	MFCD00077402

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
运输	wet ice
储存温度	?70℃
InChI	1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChI key	HKSZLNNOFSGOKW-FYTWVXJKSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)