InSolution K-252a,Nocardiopsissp.-CAS 97161-97-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (K_i= 1.8 nM), myosin light chain kinase (K_i= 17 nM), protein kinase A (K_i= 18 nM), protein kinase C (K_i= 25 nM), and protein kinase G (K_i= 20 nM). Also acts as a potent inhibitor (IC₅₀= 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of thetrkprotooncogene. Also inhibits the kinase activity of its transforming alleles, thetrkoncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.

包装

100 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
CaM kinase II
Target K_i: 1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
Product competes with ATP.
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 1 mM (100 ?g/214 ?l) solution of K-252a (Cat. No. 420298) in DMSO.

重悬

Following initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.

其他说明

Chin, L.S., et al. 1999.Cancer Invest.17,391.
Nakanishi, N., et al. 1995.FEBS Lett.368, 411.
Ross, A.H., et al. 1995.J. Neurochem.65,2748.
Mizuno, K., et al. 1993.FEBS Lett.330,114.
Pawlowska, Z., et al. 1993.J. Neurochem.60,678.
Tapley, P., et al. 1992.Oncogene7,371.
Simpson, D.L., et al. 1991.J. Neurosci. Res.28,486.
Hashimoto, S. 1988.J. Cell Biol.107,1531.
Koizuma, S., et al. 1988.J. Neurosci.8,715.
Kase, H., et al. 1987.Biochem. Biophys. Res. Commun.142,436.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C27H21N3O5
分子量	467.47

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
运输	wet ice
储存温度	?20℃
InChI	1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)
InChI key	KOZFSFOOLUUIGY-UHFFFAOYSA-N