InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀= 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀= 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 ?M for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀≥ 10 ?M). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

包装

500 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: no
Product competes with ATP.
Target IC₅₀: 5 nM against GSK-3α/β

警告

Toxicity: Carcinogenic / Teratogenic (D)

外形

A 10 mM (500 ?g/140 ?l) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

其他说明

Polychronopoulos, P., et al. 2004.J. Med. Chem.47,935.
Sato, N., et al. 2004.Nat. Med.10,55.
Meijer, L., et al. 2003.Chem. Biol.10,1255.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H10BrN3O2
分子量	356.17
MDL编号	MFCD08705318

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
运输	wet ice
储存温度	2-8℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2