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位置: 首页> 品牌> Sigma-Aldrich> InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

品牌
Sigma-Aldrich
CAS
797035-11-1
货号
565794
规格纯度
The InSolution β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
价格
2147.57 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
797035-11-1
InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem
N-(1 S, 2 R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-N'-((1 R)-1-phenylethyl)isophthalamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50= 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEVcells). Displays greater selectivity over other aspartyl proteases (IC50= 0.23 ?M, 7.6 ?M and >50 ?M for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.

包装

500 μg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
β-Secretase
Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEVcells
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 ?g/86.4 ?L) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.

其他说明

Stachel, S.J., et al. 2004.J. Med. Chem.47,6447.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C31H38N4O5S
分子量 578.72
MDL编号 MFCD09037559

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 liquid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输 dry ice
储存温度 ?70℃
SMILES string O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) 188.6 °F - (refers to pure substance)
闪点(C) 87 ℃ - (refers to pure substance)

Sigma-Aldrich

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