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Hh Signaling Antagonist X, Itraconazole-CAS 84625-61-6-Calbiochem

品牌
Sigma-Aldrich
CAS
84625-61-6
货号
419825
规格纯度
The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
价格
2012.39 *本价格含增值税费
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半岛bd体育手机客户端 名称:
84625-61-6
Hh Signaling Antagonist X, Itraconazole-CAS 84625-61-6-Calbiochem
14LDM Inhibitor, Oriconazole, R51211, Smo Antagonist VII, Sporanox, 14-α-demethylase Inhibitor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, orally available triazole-class antifungal agent that, in addition to its known inhibitory activity against fungal cytochrome P450 14-α-demethylase, also acts as an effective Hh signaling inhibitor (IC50~0.8 ?M against SHHN-induced Gli transcription activity in Shh-Light2 cells) in a Ptch-independent manner (IC50~0.9 ?M againstPtchpromoter-mediated transcription activity in murine Ptch-/-fibroblasts), presumably by binding smoothened (smo) at a site distinct from that targeted by cyclopamine (Cat. No. 239803) and SAG (Cat. No. 566660), as Itraconazole does not compete with BODIPY-cyclopamine binding, and it alters only the magnitude, but not the EC50, of SAG-induced Gli transcription activity in Shh-Light2 cells. Shown to effectively suppress Hh pathway-dependent growth of both engrafted medulloblastoma and endogenous basal cell carcinoma in micein vivo(37.5 to 100 mg/kg/12 hr, p.o.) in a reversible manner.
A cell-permeable, orally available triazole-class antifungal agent that, in addition to its known inhibitory activity against fungal cytochrome P450 14-α-demethylase, also acts as an effective Hh signaling inhibitor (IC50~ 0.8 ?M against SHHN-induced Gli transcription activity in Shh-Light2 cells) in a Ptch-independent manner (IC50~ 0.9 ?M againstPtchpromoter-mediated transcription activity in murine Ptch-/-fibroblasts), presumably by binding smoothened (smo) at a site distinct from that targeted by cyclopamine (Cat. No. 239803) and SAG (Cat. No. 566660), as Itraconazole does not compete with BODIPY-cyclopamine binding, and it alters only the magnitude, but not the EC50, of SAG-induced Gli transcription activity in Shh-Light2 cells. Shown to effectively suppress Hh pathway-dependent growth of both engrafted medulloblastoma and endogenous basal cell carcinoma in micein vivo(37.5 to 100 mg/kg/12 hr, p.o.) in a reversible manner.

包装

250 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstituiton, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kim, J., et al. 2010.Cancer Cell17,388.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C35H38Cl2N8O4
分子量 705.63
MDL编号 MFCD00870168

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 10 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
InChI key VHVPQPYKVGDNFY-ZPGVKDDISA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302 - H315 - H319 - H335
预防措施声明 P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类 Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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