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GST M5-5, Recombinant Human

品牌
Sigma-Aldrich
货号
GS59
包装型号
规格纯度
价格
5525.7 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
GST M5-5, Recombinant Human
glutathione S-transferase mu 5
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

The GSTM5 gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
Glutathione S-transferase mu 5 (GSTM5) is an enzyme that in humans is encoded by the GSTM5 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

储存及稳定性

The enzyme should be used by the end-user customer within 1 year of receipt.

半岛bd体育手机客户端 性质

质量水平 100
生物来源 human
重组 expressed inE. coli
测定 >95% (SDS-PAGE)
形式 frozen liquid
specific activity 183.9 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.)
分子量 27.4 kDa
浓度 3.2 mg/mL
储存温度 ?70℃
Gene Information human ... GSTM5(2949)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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