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GST A3-3, Recombinant Human

品牌
Sigma-Aldrich
货号
GS63
包装型号
规格纯度
价格
5525.7 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
GST A3-3, Recombinant Human
glutathione S-transferase alpha 3
GTA3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Glutathione S-transferase alpha 3 (GSTA3) is an enzyme that in humans is encoded by the GSTA3 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.

储存及稳定性

The enzyme should be used by the end-user customer within 1 year of receipt.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 >95% (SDS-PAGE)
形式 frozen liquid
specific activity 61 U/mg (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.)
分子量 25 kDa
浓度 1.0 mg/mL
储存温度 ?70℃
Gene Information human ... GSTA3(2940)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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