半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, and selective GGTase-I inhibitor. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is 25-fold more potent (IC50= 2 ?M versus 50 ?M) than FTI-277 (Cat. No. 344555) inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50= 2 ?M). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50= 2 ?M vs. 50 ?M) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50= 2 ?M). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
包装
250 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target IC50: 2 ?M against GGTase
Product does not compete with ATP.
Cell permeable: yes
Primary Target
Geranylgeranyltransferase (GGTase)
Reversible: no
警告
Toxicity: Standard Handling (A)
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
其他说明
Bredel, M., et al. 1998.Neurosurgery43,124.
Qian, Y., et al. 1998.Bioorg. Med. Chem.6,293.
Lerner, E.C., et al. 1997.Oncogene15,1283.
Lerner, E.C., et al. 1995.J. Biol. Chem.270,26770.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H31N3O3S |
| 分子量 | 429.58 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥90% (HPLC) |
| 形式 | solid (Glassy) |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 溶解性 | DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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