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GGTI-2147-CAS 191102-87-1-Calbiochem

品牌
Sigma-Aldrich
CAS
191102-87-1
货号
345885
规格纯度
A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
价格
3124.36 *本价格含增值税费
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半岛bd体育手机客户端 名称:
191102-87-1
GGTI-2147-CAS 191102-87-1-Calbiochem
4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50= 500 nM for Rap1A versus IC50>30 ?M for H-Ras).
Methyl ester derivative of GGTI-2133 (Cat. No. 345884). A potent and selective non-thiol inhibitor of geranylgeranyltransferase I (GGTase I) over farnesyltransferase (FTase) in whole cells. Blocks the geranylgeranylation of Rap1A with an IC50value greater than 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50= 500 nM for Rap1A versus IC50<30 ?M for H-Ras).

包装

250 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 500 nM in blocking the geranyl-geranylation of Rap1A
Product does not compete with ATP.
Reversible: no
Primary Target
GGTase-I

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bernot, D., et al. 2003.J. Cardiovasc. Pharmacol.41,316.
Vasudevan, A., et al. 1999.J. Med. Chem.42,1333.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H30N4O3
分子量 470.56

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 off-white
溶解性 DMSO: 200 mg/mL
运输 ambient
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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