半岛bd体育手机客户端 说明
一般描述
A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50= 500 nM for Rap1A versus IC50>30 ?M for H-Ras).
Methyl ester derivative of GGTI-2133 (Cat. No. 345884). A potent and selective non-thiol inhibitor of geranylgeranyltransferase I (GGTase I) over farnesyltransferase (FTase) in whole cells. Blocks the geranylgeranylation of Rap1A with an IC50value greater than 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50= 500 nM for Rap1A versus IC50<30 ?M for H-Ras).
包装
250 μg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 500 nM in blocking the geranyl-geranylation of Rap1A
Product does not compete with ATP.
Reversible: no
Primary Target
GGTase-I
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Bernot, D., et al. 2003.J. Cardiovasc. Pharmacol.41,316.
Vasudevan, A., et al. 1999.J. Med. Chem.42,1333.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C28H30N4O3 |
分子量 | 470.56 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | solid |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze desiccated (hygroscopic) |
颜色 | off-white |
溶解性 | DMSO: 200 mg/mL |
运输 | ambient |
储存温度 | ?20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |