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Ellagic Acid, Dihydrate-CAS 476-66-4-Calbiochem

品牌
Sigma-Aldrich
CAS
476-66-4
货号
324683
规格纯度
A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties.
价格
1364.79 *本价格含增值税费
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半岛bd体育手机客户端 名称:
476-66-4
Ellagic Acid, Dihydrate-CAS 476-66-4-Calbiochem
4,4',5,5',6,6'-Hexahydroxydiphenic Acid 2,6,2',6'-Dilactone, TBBD, PRMT Inhibitor II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50= 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50= 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 ?M, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50>40 ?M). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50= 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50= 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 ?M, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50>40 ?M). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.

包装

500 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
CDK2
Target IC50: 40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 ?M, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Irritant (B)

制备说明

For complete solubilization in ethanol, slight heating may be required.

重悬

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.

其他说明

Selvi, B.R., et al. 2009,J. Biol. Chem.In press.
Cozza, G., et al. 2006.J. Med. Chem.49,2363.
Wang, B.H., et al. 1998.Planta Med.64,195.
Constantinou, A., et al. 1995.Nutr. Cancer23,121.
Hickey, M.J., et al. 1995.Biochem. Soc. Trans.23,607s.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H6O8· 2H2O
分子量 338.22
MDL编号 MFCD00006914

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 slightly beige
溶解性 1 M NaOH: 10 mg/mL
ethanol: 10 mg/mL
运输 ambient
储存温度 10-30℃
InChI 1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
InChI key AFSDNFLWKVMVRB-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P264 - P270 - P301 + P312 - P501
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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