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位置: 首页> 品牌> Sigma-Aldrich> Diltiazem, Hydrochloride-CAS 33286-22-5-Calbiochem

Diltiazem, Hydrochloride-CAS 33286-22-5-Calbiochem

品牌
Sigma-Aldrich
CAS
33286-22-5
货号
309866
规格纯度
Synthetic benzothiazepine that acts as an L-type Ca2+channel antagonist.
价格
1030.48 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
33286-22-5
Diltiazem, Hydrochloride-CAS 33286-22-5-Calbiochem
L-Type Calcium Channel Blocker II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Synthetic benzothiazepine that acts as an L-type Ca2+channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+release from intracellular stores in neutrophils.
Synthetic (+)-cis isomer that acts as an L-type Ca2+channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca2+release from intracellular stores in neutrophils.

包装

100 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
L-type Ca2+ channel
Cell permeable: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

其他说明

van Zwieten, P.A., and Pfaffendorf, M. 1993.J. Hypertens. Suppl.11,S3.
Rosales, C., and Brown, E.J. 1992.J. Biol. Chem.267,1443.
Julian, D.G. 1987.Am. J. Cardiol.59,37J.
Campbell, K.P., et al. 1986.Proc. Natl. Acad. Sci. USA83,2792.
Gallizzi, J.P., et al. 1986.J. Biol. Chem.261,1393.
Garcia, M.L., et al. 1986.J. Biol. Chem.261,8146.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C22H26N2O4S · xHCl
分子量 414.52 (free base basis)
MDL编号 MFCD00069252
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性 water: 50 mg/mL
chloroform: soluble
methanol: soluble
运输 ambient
储存温度 10-30℃
InChI 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key HDRXZJPWHTXQRI-BHDTVMLSSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P264 - P270 - P301 + P312 - P501
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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