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DHSO crosslinker

品牌
Sigma-Aldrich
CAS
1971857-82-5
货号
909599
包装型号
规格纯度
价格
2718.6 *本价格含增值税费
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半岛bd体育手机客户端 名称:
1971857-82-5
DHSO crosslinker
3,3′-Sulfinyldi(propanehydrazide)
Dihydrazide sulfoxide
Mass spectrometry-cleavable crosslinker for studying protein-protein interations
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

DHSO Crosslinker is a homobifunctional, acidic residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). DHSO possesses two hydrazide-reactive groups for targeting aspartic acid (Asp) and glutamic acid (Glu) and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. While former amine-reactive reagents react with lysine (Lys) residues in proximity to the PPI, targeting acidic residues provides further opportunity to characterize protein interaction surfaces at which Asp and Glu are often prevalent. Additionally, the 12.4 ? spacer yields tagged peptides post-cleavage for unambiguous identification by collision-induced dissociation in tandem MS. DHSO Crosslinker provides complementary data to Lys-targeting reagents and will find wide utility in the elucidation of PPIs, study of proteins that function as complexes, quantification of structural dynamics, and quest for targeting "undruggable" protein targets.

其他说明

Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein Interactions

Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein–Protein Interactions

Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein–Protein Interactions

Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling

法律信息

Subject to US Patent Application #15/613,065 of the Regents of the University of California

基本信息

经验(实验)分子式 C6H14N4O3S
分子量 222.27

半岛bd体育手机客户端 性质

形式 powder
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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