CBP-CREB Interaction Inhibitor-CAS 92-78-4-Calbiochem

品牌

Sigma-Aldrich

CAS

92-78-4

货号

217505

包装型号

250 MG, The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

规格纯度

The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

价格

1364.79 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

92-78-4
CBP-CREB Interaction Inhibitor-CAS 92-78-4-Calbiochem
Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-freeRenillaluciferase (RLuc) complementation assays (IC₅₀= 2.26 and 2.9 M, respectively) by directly binding to CBP′s KIX domain (K_d~8.6 M using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin in a HEK293T-based RLuc reporter assay (IC₅₀<2.5 M), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity ofFireflyluciferase (IC₅₀~1 M), but not that of RLuc.
A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-freeRenillaluciferase (RLuc) complementation assays (IC₅₀= 2.26 and 2.9 ?M, respectively) by directly binding to CBP′s KIX domain (K_d~8.6 ?M using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC₅₀<2.5 ?M), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity ofFireflyluciferase (IC₅₀~1 ?M), but not that of RLuc.

包装

250 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Li, B.X. and Xiao, X., 2009.ChemBioChem10,2721.
Best, J.L., et al. 2004.Proc. Natl. Acad. Sci. USA101,17622.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₁₂ClNO₂
分子量	297.74

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
InChI key	OHAXNCGNVGGWSO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H319
预防措施声明	P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Sens. 1B
储存分类代码	11 - Combustible Solids
WGK	WGK 1