半岛bd体育手机客户端 说明
一般描述
Corresponds to a C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin. Specific calcineurin inhibitor. Does not inhibit CaM kinase II, protein phosphatase I or 2A. Inhibits Mn2+-stimulated calcineurin activity (IC50= 10 ?M using32P myosin light chain as a substrate) but has no effect on Ni2+-stimulated activity.
Specific calcineurin inhibitor. Corresponds to the C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin (PP2B). Inhibits Mn2+-stimulated calcineurin activity (IC50= 10 ?M using32P-myosin light chain as a substrate) but has no effect on Ni2+-stimulated enzyme activity. Does not inhibit CaM kinase II, protein phosphatase 1 or 2A.
包装
250 μg in Plastic ampoule
Yes
生化/生理作用
Product does not compete with ATP.
Primary Target
Mn2+-stimulated calcineurin activity
Reversible: no
Cell permeable: no
Target IC50: 10 ?M using 32P-myosin light chain as a substrate
警告
Toxicity: Standard Handling (A)
序列
H-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C.
其他说明
Perrino, B.A., et al. 1995.J. Biol. Chem.270,340.
Yokoyama, Y., and Wang, J.H. 1994.FEBS Lett.337,128.
Yokoyama, N., et al. 1993.Arch. Biochem. Biophys.300,615.
Matsui, H., et al. 1991.Biochem. Int.24,1119.
Hashimoto, Y., et al. 1990.J. Biol. Chem.265,1924.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C124H205N39O39S2 |
| 分子量 | 2930.32 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | lyophilized |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 溶解性 | water: soluble |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
