Caffeic Acid-CAS 331-39-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID₅₀= 3.7 ?M). Inhibits Cu²⁺-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An effective irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.
A natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A cell-permeable, selective, non-competitive inhibitor of 5-lipoxygenase (ID₅₀= 3.7 ?M). Inhibits Cu²⁺-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.

包装

500 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
5-lipoxygenase
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 3.7 ?M against 5-lipoxygenase

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yamanaka, N., et al. 1997.FEBS Lett.405,186.
Chan, W.S., et al. 1995.Anticancer Res.15,703.
Ploemen, J.H., et al. 1993.Food Chem. Toxicol.31,475.
Koshihara, Y., et al. 1984.Biochim. Biophys. Acta792,92.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C9H8O4
分子量	180.16
MDL编号	MFCD00004392

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	crystalline solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	tan
溶解性	DMSO: 200 mg/mL ethanol: 50 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2-
InChI key	QAIPRVGONGVQAS-RQOWECAXSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H351
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Carc. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable