BocA1V1PF2

品牌

Sigma-Aldrich

货号

917478

包装型号

100 MG, ≥95%

规格纯度

≥95%

价格

4588.91 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

BocA1V1PF2
( S)-2-(( S)-1-((S)-2-(( S)-2-(( tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid
IAP E3 ligase lead for protein degrader research
AVP ligand
SNIPER building block

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710).

BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^?degrader libraries: Degrader Building Blocks
916927 BocA1V1PF2-OC₆-NH₂hydrochloride
917184 BocA1V1PF2-OC₁₀-NH₂hydrochloride
917435 BocA1V1PF2-OPEG₁-NH₂hydrochloride
917680 BocA1V1PF2-OPEG₃-NH₂hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

其他说明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs?Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₂₈H₄₁FN₄O₇
分子量	564.65

半岛bd体育手机客户端性质

质量水平	100
测定	≥95%
形式	powder
储存温度	2-8℃
SMILES string	C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable