半岛bd体育手机客户端 说明
一般描述
A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is also a potent inhibitor of DNA topoisomerase II. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA has been reported to stimulate the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase C-γ. Dye content: ~85%.
A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50= 22 ?M and IC50= 10 ?M for ?-calpain and m-calpain, respectively).
Dye content: ~85%.
包装
100 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
DNA topoisomerase 2
Target IC50: 75 nM against DNA topoisomerase II
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Lozano, R.M., et al. 1997.Eur. J. Biochem.248,30.
Benchokroun, Y., et al. 1995.Biochem. Pharmacol.49,305.
Okada, N., and Koizumi, S. 1995.J. Biol. Chem.270,16464.
Posner, A., et al. 1995.Biochem. Mol. Biol. Int.36,291.
Catchpoole, D.R., et al. 1994.Anticancer Res.14,853.
Csernansky, C.A., et al. 1994.J. Neurosci. Res.38,101.
Gagliardi, A.R., and Collins, D.C. 1994.Anticancer Res.14,475.
Gonzalez, R.G., et al. 1980.Biochemistry19,4299.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C22H14O9 |
| 分子量 | 422.34 |
| MDL编号 | MFCD00011663 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥85% (titration) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | red |
| 溶解性 | 0.1 M NaOH: 35 mg/mL |
| 运输 | ambient |
| 储存温度 | 10-30℃ |
| InChI | 1S/C22H16O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-10,19,24-25H,(H,26,27)(H,28,29)(H,30,31);3*1H3 |
| InChI key | UDPQMNAHKKTHHI-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
