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Anti-TGM2 (AB2) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV47472
规格纯度
affinity isolated antibody
价格
6889.23 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-TGM2 (AB2) antibody produced in rabbit
Anti-TGC
Anti-transglutaminase 2 (C polypeptide, protein-glutamine-γ-glutamyltransferase)
Anti-TG2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TGM2 codes for a transglutaminase that catalyzes the crosslinking of protein via epsilon-gamma glutamyl lysine isopeptide bonds. Tgm2/Gh is known to play a role in the retinoic acid-induced transdifferentiation of mucosal epithelial cells. It functions as a biomarker for predicting treatment efficacy in laryngeal cancer patients undergoing radiotherapy. It is also associated with drug sensitivity in breast cancer.
Rabbit Anti-TGM2 antibody recognizes human, mouse, rat, and bovineTGM2.

免疫原

Synthetic peptide directed towards the N terminal region of human TGM2

应用

Rabbit Anti-TGM2 antibody is suitable for western blot applications at a concentration of 0.5 μg/ml.

生化/生理作用

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

序列

Synthetic peptide located within the following region: MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNY

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 77 kDa
species reactivity human
浓度 0.5 mg - 1 mg/mL
technique(s) western blot: suitable
NCBI登记号 NP_004604
UniProt登记号 P21980
运输 wet ice
储存温度 ?20℃
Gene Information human ... TGM2(7052)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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