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位置: 首页> 品牌> Sigma-Aldrich> Anti-EDEM1 antibody,Mouse monoclonal

Anti-EDEM1 antibody,Mouse monoclonal

品牌
Sigma-Aldrich
货号
E8159
规格纯度
clone EDEM1-17, purified from hybridoma cell culture
价格
4574.61 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-EDEM1 antibody,Mouse monoclonal
Anti-ER degradation enhancer, mannosidase alpha-like 1
Anti-EDEM
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-EDEM1 (mouse IgG2a isotype) is derived from the hybridoma EDEM1-17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human EDEM1. conjugated to keyhole limpet hemocyanin (KLH). EDEM1 (ER degradation-enhancing alphamannosidase-like protein 1) is a putative mannose binding lectin. In mammalian cells, EDEM1 is localized to the endoplasmic reticulum (ER), mainly as a soluble glycoprotein.

应用

Monoclonal Anti-EDEM1 antibody produced in mouse has been used in:

  • immunoblotting
  • immunoprecipitation
  • immuno-electron microscopy
  • immunohistochemistry (IHC)

生化/生理作用

EDEM1 (ER degradation-enhancing alphamannosidase-like protein 1) has the ability to interact with the COOH-terminus of calnexin. It lacks mannosidase activity.
ER degradation-enhancing α-mannosidase-like 1 is an enzyme encoded by the EDEM1 gene in humans. It is a chaperone for rod opsin and its expression can be used to promote correct folding enhancing degradation of mutant proteins in the ER to combat protein-misfolding disease. The endogenous EDEM1 in cells that are not stressed by the expression of a transgenic misfolded protein reaches the cytosol and is degraded by basal autophagy. EDEM may maintain the retrotranslocation competence of NHK by inhibiting aggregation. It is also considered responsible for directing aberrant proteins for ERAD (ER-associated protein degradation).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 EDEM1-17, monoclonal
形式 buffered aqueous solution
分子量 antigen 75/65 kDa
species reactivity human, mouse
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells expressing recombinant human or mouse EDEM1
同位素/亚型 IgG2a
UniProt登记号 Q92611
运输 dry ice
储存温度 ?20℃
Gene Information human ... EDEM1(9695)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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