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位置: 首页> 品牌> Sigma-Aldrich> Anti-Catenin delta-2 Antibody, clone 4H2.1

Anti-Catenin delta-2 Antibody, clone 4H2.1

品牌
Sigma-Aldrich
货号
MABN2330
规格纯度
clone 4H2.1, from mouse
价格
1415.25 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Catenin delta-2 Antibody, clone 4H2.1
Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Catenin delta-2 (UniProt: Q9UQB3; also known as Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin) is encoded by the CTNND2 (also known as NPRAP) gene (Gene ID: 1501) in human. Delta Catenin is a component of the cadherin-catenin cell adhesion complex and is enriched in synaptosomes. Catenin Delta 2 is a member of the beta-catenin superfamily and is expressed in the brain where it is required for normal cognitive development and its highest expression is observed in fetal brain. Catenin Delta 2 is phosphorylated by Cdk5 and by GSK-3beta. Catenin Delta 2 plays a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. It is also involved in the regulation of Wnt signaling where it acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3beta, phosphorylation, ubiquitination, and degradation. When bound to ZBTB33 (Zinc Finger and BTB Domain Containing 33), it functions as a transcriptional activator. Catenin delta-2 also promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. Two isoforms of Catenin delta-2 have been reported that are produced by alternative splicing. It has nine Armadillo (ARM) repeats and a coiled coil region (aa 49-84). Defects in CTNND2 gene are known to cause autism and delayed acquisition of psychomotor skills. (Ref.: Yuan, L et al. (2015). J. Biol. Chem. 290(17):10947-57).

特异性

Clone 4H2.1 specifically detects Catenin delta-2 in human and murine cells. It targets an epitope with in the C-tereminal region.

免疫原

GST/His-tagged recombinant fragment corresponding to 145 amino acids from the C-terminal region of human Catenin delta-2.

应用

Anti-Catenin delta-2, clone 4H2.1 Antibody, Cat. No. MABN2330, is a highly specific mouse monoclonal antibody that targets Catenin delta-2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Immunohistochemistry (Paraffin) Analysis: A 1:50-250 dilution from a representative lot detected Catenin delta-2 in rat thalamus, rat cerebellum, and human cerebral cortex tissue sections.

Research Category
Neuroscience

质量

Evaluated by Western Blotting in mouse cerebellum tissue lysate.

Western Blotting Analysis: 0.02 ?g/mL of this antibody detected Catenin delta-2 in mouse cerebellum tissue lysate.

目标描述

~150 kDa observed; 132.66 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Protein G purified
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 4H2.1, monoclonal
species reactivity human, mouse
包装 antibody small pack of 25 μg
technique(s) immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型 IgG2bκ
NCBI登记号 NP_001323
UniProt登记号 Q9UQB3
Gene Information human ... CTNND2(1501)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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