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位置: 首页> 品牌> Sigma-Aldrich> AhR Antagonist-CAS 301326-22-7-Calbiochem

AhR Antagonist-CAS 301326-22-7-Calbiochem

品牌
Sigma-Aldrich
CAS
301326-22-7
货号
182705
规格纯度
The AhR Antagonist, also referenced under CAS 301326-22-7, controls the biological activity of AhR.
价格
2741.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
301326-22-7
AhR Antagonist-CAS 301326-22-7-Calbiochem
2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4- o-tolyl-azophenyl)-amide, CH-223191
2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4- o-tolyl-azophenyl)-amide, CH-223191
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cellsin vitro(IC50= 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in micein vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 ?M.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cellsin vitro
Product does not compete with ATP.
Reversible: no
Primary Target
AhR (aryl hydrocarbon receptor)

警告

Toxicity: Irritant (B)

其他说明

Kim, S.H., et al. 2006.Mol. Pharmacol.69,1871.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C19H19N5O
分子量 333.39
MDL编号 MFCD00377884

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 orange-brown
溶解性 DMSO: 10 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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