AdaAhx₃L₃VS-CAS 389064-25-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 ?M), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 ?M) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 ?M).
A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 ?M), and PGPH (0.5-1 ?M) activities of the 20S proteasome.

包装

250 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 50-100 nM against chymotrypsin-like activity of the 20S proteasome
Primary Target
chymotrypsin-like activity of the 20S proteasome
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kessler, B.M., et al. 2001.Chem. Biol.8,913.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息