半岛bd体育手机客户端 说明
应用
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC?molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
其他说明
Technology Spotlight: Proteomic Ligandability Assessment
The Proteome-Wide Potential for Reversible Covalency at Cysteine
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Proteome-wide covalent ligand discovery in native biological systems
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
基本信息
| 经验(实验)分子式 | C12H14ClNO2 |
| 分子量 | 239.70 |
| MDL编号 | MFCD09376367 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% |
| 形式 | chunks |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
