半岛bd体育手机客户端 说明
应用
2-(4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
其他说明
Portal: Building PROTAC?Degraders for Targeted Protein Degradation
Crosslinkers for Bioconjugation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
基本信息
| 经验(实验)分子式 | C18H25NO4 |
| 分子量 | 319.40 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% |
| 形式 | powder |
| mp | 164-170 ℃ |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(OC(C)(C)C)N1CCC(C2=CC=C(CC(O)=O)C=C2)CC1 O=C(OC(C)(C)C)N1CCC(C2=CC=C(CC(O)=O)C=C2)CC1 |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H315 - H317 - H319 - H410 |
| 预防措施声明 | P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
